11/7/2022 0 Comments Omicron“There has been a lot of focus on spike, but we’re seeing in our system that for both Delta and Omicron, the nucleocapsid is really more important in enhancing the spread of this virus,” says Ott. And virus-like particles carrying Omicron’s mutations in the nucleocapsid protein were 30 times more infectious than the ancestral SARS-CoV-2. Omicron mutations in the spike protein, they found, made virus-like particles twice as infectious as those with the ancestral spike protein. Recently, the team developed virus-like particles to capture the effect of different mutations in the emerging Omicron variant of SARS-CoV-2. For example, based on cell culture experiments, if a virus-like particle carrying a certain mutation was more effective at producing viral particles, a copy of the live virus with the same mutation was also more infectious. The researchers previously showed how the infectivity of the corresponding full, live virus was linked to the effectiveness of virus-like particle assembly. Additionally, researchers can create new virus-like particles far more quickly than they can grow new variants of the live virus to analyze. However, because virus-like particles are devoid of the virus’s genome, they cannot infect humans and are less dangerous to deal with than the live virus. These particles are made up of the viral particle’s structure’s membrane, envelope, nucleocapsid, and spike proteins. To research the SARS-CoV-2 virus, Ott and Doudna’s research teams created virus-like particles in the early months of 2021. It has also resulted in a greater number of breakthrough infections than other variations, in people previously infected with or fully vaccinated against COVID-19. Credit: Michael Short/Gladstone Institutes Virus-Like Particles Accelerate Omicron ResearchĮpidemiological evidence has indicated that the Omicron variant of SARS-CoV-2, which was discovered for the first time in November 2021 in South Africa, spreads more rapidly than the virus’s original strain. A team of researchers, including Abdullah Syed (left) and Alison Ciling (right), used virus-like particles to identify which parts of the SARS-CoV-2 virus are responsible for its increased infectivity and spread.
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